Boin bolestra
WebBayesian optimal interval (BOIN) design is a model-assisted phase I dose-finding design to find the maximum tolerated dose (MTD). The hallmark of the BOIN design is its concise decision rule - making the decision of dose escalation and de-escalation by simply comparing the observed dose-limiting toxicity (DLT) rate at the current dose with a pair of … Web2.2. Local BOIN design In the interval design, the selection of the interval boundaries λ 1j(nj,φ) and λ 2j(nj,φ) is critical because these two parameters essentially determine the …
Boin bolestra
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WebDec 22, 2024 · The BOIN Design Program provides a novel platform for designing various phase I clinical trials, including single-agent and drug-combination trials, as well as trials with late-onset toxicity. The program … Web2.2. Local BOIN design In the interval design, the selection of the interval boundaries λ 1j(nj,φ) and λ 2j(nj,φ) is critical because these two parameters essentially determine the operating characteristics of the design. To simplify the notations, we suppress the arguments nj and φ in λ 1j(nj,φ) and λ 2j(nj,φ). In the following ...
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