WebDec 16, 2024 · Elevated plus maze The elevated plus maze (EPM) was used to assess exploratory behavior and anxiety levels [ 31 ]. The EPM is raised 75 cm above a padded surface and consists of four arms in a “ + ” configuration of 15-cm length and 5-cm width. WebFeb 1, 2000 · The elevated plus-maze and the light/dark box are two established anxiety tests in rodents, which are useful to screen putative anxiogenic effects of drugs. Objective Caffeine is well known to promote anxious behaviour in humans and animal models, but the precise site of action of the drug is still a matter of debate.
Effects of Ethanol and Caffeine on Behavior in C57BL/6 Mice …
Weban elevated plus-maze with two open and two closed arms. Two indices of anxiety are obtained: the number of entries into open arms expressed as a percentage of the total ... caffeine, FG 7142 and d-amphetamine were used as agents with anxiogenic actions (File and Hyde 1979; Dorow et al. 1983; Charney et al. 1984; File and Lister 1984; Pellow ... black white fancy dress outfits
The use of a plus-maze to measure anxiety in the mouse
WebThe elevated plus maze ( EPM) is a test measuring anxiety in laboratory animals that usually uses rodents as a screening test for putative anxiolytic or anxiogenic compounds and as a general research tool in neurobiological anxiety … WebThe modified elevated plus-maze consisted of a wood base and gray Plexiglas floors and walls with no top. The entire maze was 36 off the ground, with two opposing enclosed (walled) arms ... constructed a dose-response curve for the effects of caffeine on plus-maze discriminative avoidance. Caffeine (5–40 mg/kg) or WebBehavioral testing for anxiety-related behavior began in adulthood (P62) 7 days after removal of caffeine. Adolescent caffeine consumption enhanced anxiety-related behavior in an open field, social interaction test, and elevated plus maze. Similar caffeine consumption in adult rats did not alter anxiety-related behavior after caffeine removal. foxrates