Cyclothialidine
WebFeb 1, 2010 · The crystal structures of compounds 1 and 2 23 with 24 kDa N-terminal fragment of the DNA gyrase B protein offer valuable information for lead optimization process. It has been demonstrated that the noviose sugar of novobiocin (1) and resorcinol moiety of cyclothialidine GR122222X (2) are involved in a similar H-bond network … WebJan 1, 1993 · Cyclothialidine is a new, potent DNA gyrase inhibitor isolated from Streptomyces filipinensis. However, it exhibits hardly any growth-inhibitory activity …
Cyclothialidine
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WebDescription: Cyclothialidine is a DNA gyrase inhibitor; isolated from Streptomyces filipinensis. Chemical Structure Cyclothialidine CAS# 147214-63-9 Instruction Theoretical Analysis MedKoo Cat#: 596819 …
WebAug 15, 2007 · From the SAR around cyclothialidine 2 we know that the introduction of a methoxy and a carboxylic ester group in the meta positions and a lipophilic group (like methyl) in para position to the phenol improves activity. Therefore we coupled the salicylic aldehyde 4a with various anilines to yield the acyclic benzylic amines 5 and the 2,3 … WebOct 1, 1994 · We investigated how cyclothialidine (Ro 09-1437), a novel DNA gyrase inhibitor belonging to a new chemical class of compounds, acts to inhibit Escherichia coli DNA gyrase. Cyclothialidine up to...
WebJun 16, 1995 · Cyclothialidine contains a unique 12-membered lactone ring that is partly integrated into a pentapeptide chain(21). Cyclothialidine exhibited the highest … WebCombining molecular docking and QSAR studies for modelling the antigyrase activity of cyclothialidine derivatives. Liane Saíz-Urra, Miguel Ángel Cabrera Pérez, Aliuska Morales Helguera, Matheus Froeyen. Pages 2736-2747 Download PDF. Article preview.
WebCyclothialidine C C26H35N5O11S CID 10699166 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological ...
WebThecyclo- thialidinesarenaturallyoccurringcyclicpeptideinhibitors (Goetschietal., 1993), ofwhichGR122222Xisamember (Figure 1), andarealso inhibitors ofthe ATPase activity of the B subunit of DNAgyrase(Nakadaetal., 1994). magic chain mail 5eWebAntioxidative Antiviral Bioactive by-products Cyclosporin Analogue Set Enzyme inhibitors Mycotoxins Raw Materials of Healthcare Products Tacrolimus Analogue Set Others International : 1-631-504-6093 US & Canada (Toll free): 1-844-BOC (262)-0123 Fax: 1-631-614-7828 Email: [email protected] 45-16 Ramsey Road, Shirley, NY 11967, USA magic chain crochetWebCyclothialidine D * Please be kindly noted products are not for therapeutic use. We do not sell to patients. Category: Enzyme inhibitors: Catalog number: BBF-01121: CAS: 194276-78-3: Molecular Weight: magic chain floating wine bottle holderWebMar 11, 2004 · Cyclothialidine (1, Ro 09-1437) is a potent DNA gyrase inhibitor that was isolated from Streptomyces filipinensis NR0484 and is a member of a new family of … magic challenge judo slothWebDec 9, 2003 · Cyclothialidine (1, Ro 09-1437) is a potent DNA gyrase inhibitor that was isolated from Streptomyces filipinensis NR0484 and is a member of a new family of … magic champions codes workingWebApr 1, 1996 · We present the structures of a 24 kDa N-terminal fragment of the Escherichia coli DNA gyrase B protein in complexes with two different inhibitors of the ATPase activity of DNA gyrase, namely the... magic c handwritingWebCyclothialidine (1, Ro 09-1437) is a potent DNA gyrase inhibitor that was isolated from Streptomyces filipinensisNR0484 and is a member of a new family of natural products. magic change man to woman