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Hct 116 is atra sensitive or atra resistant

WebMay 1, 2024 · To assess whether UBE2L6 expression is important for leukemic cell differentiation—two cell line models were employed: the human APL cell line NB4 and its ATRA‐resistant NB4R counterpart, as well as the ATRA‐sensitive human AML HL60 cells along with their ATRA‐resistant subclone—HL60R. ATRA strongly induced UBE2L6 in … WebAug 28, 2013 · Ful-R cells, a fulvestrant resistant cell line derived from a single cell clone of MCF-7, were more sensitive to ATRA than MDA-MB-436 and MDA-MB-231 cells, which …

[Effects of interferon-gamma combined with all-trans retinoic ... - PubMed

WebRAR-mutated HCT-116 colon cancer cells were incubated for 3, 12, or 24 h in the presence or absence of 1 μM ATRA. (A) qPCR for CysLT2R expression in HCT-116 cells. Data are normalized to HPRT-1. Webby ATRA in combination with activation of PPRE by PPARγ, ligand CDDO will induce de-silencing of downstream genes and induce differentiation in ATRA-sensitive and ATRA-resistant APL. As a model, we used APL-derived NB4 cells, its ATRA-resistant clone MR2 (Rosenauer 1996, ref. 23) and an in vivo APL model patricia carmichael line of duty https://proteksikesehatanku.com

Independent Mechanism − Cancer Cells through a Retinoic Acid …

WebJul 8, 2013 · The colon cancer cell lines Caco-2, SW480 (ATRA-sensitive), and HCT-116 (ATRA-resistant) [ 30] were grown in Dulbecco’s modified Eagle medium with 100 μM non-essential amino acids, RPMI 1640, and McCoy’s 5A medium, respectively. WebCT.GOV-Connecticut's Official State Website WebBreast cancer cells which were resistant to atRA, were also resistant to BMS453. Normal human breast cells were most sensitive to the anti-proliferative effects of BMS453. These results indicate that in some breast cells RAR-dependent transactivation is not necessary for retinoids to inhibit growth. patricia carmichael

Retinoic acid receptor antagonist BMS453 inhibits the growth

Category:Mechanical phenotyping of acute promyelocytic leukemia …

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Hct 116 is atra sensitive or atra resistant

Mechanical phenotyping of acute promyelocytic leukemia

WebNov 1, 2005 · We examined the ability of retinol to inhibit the growth of ATRA-sensitive (HCT-15) and ATRA-resistant (HCT-116, SW620, and WiDR) human colon cancer cell … WebHCT 116 Cell Line. HCT116 is a human colorectal carcinoma cell line initiated from an adult male. The cells are adherent with an epithelial morphology. Following implantation into …

Hct 116 is atra sensitive or atra resistant

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WebHCT-15 (A) HCT-116 (B), SW620 (C ), and WiDR (D ) cells were seeded and treated with 0, 0.1, 1, or 10 Amol/L ATRA or retinol. All treatments were performed in duplicate. Cells … WebCopyright by Eunyoung Park 2007 - The University of Texas at Austin

WebHowever, retinoic acid resistance limits the chemotherapeutic potential of ATRA. We examined the ability of retinol to inhibit the growth of ATRA-sensitive (HCT-15) and … WebChapter 2: Retinol Inhibits the Growth of All-Trans-Retinoic Acid-. Sensitive and -Resistant Colon Cancer Cells through a Retinoic Acid. Receptor-Independent Mechanism. ABSTRACT

WebBreast cancer cells which were resistant to atRA, were also resistant to BMS453. Normal human breast cells were most sensitive to the anti-proliferative effects of BMS453. … WebMay 29, 2024 · While all-trans retinoic acid (ATRA) is an essential therapy in the treatment of acute promyelocytic leukemia (APL), an aggressive subtype of acute myeloid …

WebOct 30, 2024 · Results. We constructed an effective model of ATRA-induced HL-60 differentiation which described signaling and gene expression events following the … patricia carragher esqWebOct 24, 2024 · We identified over 1400 sites that were differentially methylated between atRA resistant and sensitive cell lines. These CpG sites predicted the response of four TNBC patient-derived xenografts to atRA, and we utilized these xenografts to refine the profile and identified that as many as 17% of TNBC patients could benefit from atRA … patricia carrasco zambranoWebMay 8, 2013 · Notably, PHF8 expression was much lower in an ATRA-resistant APL cell line than in its ATRA-sensitive parental cell line, suggesting that PHF8 regulates ATRA sensitivity in APL cells. ... Although it remains to be shown whether PHF8 expression is decreased in ATRA-resistant patients, these findings provide insight into the molecular … patricia carol “patty” helfrichWebCLOSE TRY ADFREE ; Self publishing ; Discover patricia carrereWebTo discern the underlying mechanism for the treatment response of the xenografts, in vitro HCT-116 cell cultures were investigated with enzymatic assays, cell cycle analysis, and … patricia caroline swanson feldman carlsonWebJan 2, 2012 · As predicted, on the basis of relative FABP5 and CRABP2 expression, we determined that FABP5 high CRABP2 null cells (Pa04C and Pa14C) were resistant, whereas FABP5 null CRABP2 high cells (Pa01C and Pa03C) were sensitive to ATRA at concentrations up to 10 μmol/L on MTS assays ( Fig. 1C ). patricia carranzaWebMany researches indicate that the mechanism of ATRA-resistance is related to lack of some proteins synthesized by interferon (IFN). This study was to explore the possibility and the possible mechanism of treating ATRA-resistant APL with IFN in … patricia carolina rivas guerin