WebMay 1, 2024 · To assess whether UBE2L6 expression is important for leukemic cell differentiation—two cell line models were employed: the human APL cell line NB4 and its ATRA‐resistant NB4R counterpart, as well as the ATRA‐sensitive human AML HL60 cells along with their ATRA‐resistant subclone—HL60R. ATRA strongly induced UBE2L6 in … WebAug 28, 2013 · Ful-R cells, a fulvestrant resistant cell line derived from a single cell clone of MCF-7, were more sensitive to ATRA than MDA-MB-436 and MDA-MB-231 cells, which …
[Effects of interferon-gamma combined with all-trans retinoic ... - PubMed
WebRAR-mutated HCT-116 colon cancer cells were incubated for 3, 12, or 24 h in the presence or absence of 1 μM ATRA. (A) qPCR for CysLT2R expression in HCT-116 cells. Data are normalized to HPRT-1. Webby ATRA in combination with activation of PPRE by PPARγ, ligand CDDO will induce de-silencing of downstream genes and induce differentiation in ATRA-sensitive and ATRA-resistant APL. As a model, we used APL-derived NB4 cells, its ATRA-resistant clone MR2 (Rosenauer 1996, ref. 23) and an in vivo APL model patricia carmichael line of duty
Independent Mechanism − Cancer Cells through a Retinoic Acid …
WebJul 8, 2013 · The colon cancer cell lines Caco-2, SW480 (ATRA-sensitive), and HCT-116 (ATRA-resistant) [ 30] were grown in Dulbecco’s modified Eagle medium with 100 μM non-essential amino acids, RPMI 1640, and McCoy’s 5A medium, respectively. WebCT.GOV-Connecticut's Official State Website WebBreast cancer cells which were resistant to atRA, were also resistant to BMS453. Normal human breast cells were most sensitive to the anti-proliferative effects of BMS453. These results indicate that in some breast cells RAR-dependent transactivation is not necessary for retinoids to inhibit growth. patricia carmichael