Human sdf-1a
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The stromal cell-derived factor 1 (SDF-1), also known as C-X-C motif chemokine 12 (CXCL12), is a chemokine protein that in humans is encoded by the CXCL12 gene on chromosome 10. It is ubiquitously expressed in many tissues and cell types. Stromal cell-derived factors 1-alpha and 1-beta are small … See more Gene The CXCL12 gene resides on chromosome 10 at the band 10q11.1 and contains 9 exons. This gene produces 7 isoforms through alternative splicing. Protein See more CXCL12 is expressed in many tissues in mice including brain, thymus, heart, lung, liver, kidney, spleen, platelets and bone marrow. CXCL12 is strongly chemotactic for lymphocytes. … See more In humans, CXCL12 has been implicated in a wide variety of biomedical conditions involving several organ systems. Furthermore, … See more • Kucia M, Reca R, Miekus K, Wanzeck J, Wojakowski W, Janowska-Wieczorek A, Ratajczak J, Ratajczak MZ (August 2005). "Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF-1-CXCR4 axis" See more WebStromal Cell-Derived Factor-1 alpha Human Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 68 amino acids and having a molecular mass …
Human sdf-1a
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WebThe Human SDF-1 alpha solid-phase sandwich ELISA (enzyme-linked immunosorbent assay) is designed to measure the amount of the target bound between a matched … WebIn 1996, Feng et al. found that CXCR4 acted as an essential co-receptor for T cell-tropic strains of human immunodeficiency virus type-1 (HIV-1), and Bleul et al. and Oberlin et al. demonstrated that CXCL12 had HIV-suppressive activities (9, 10). Furthermore, CXCL12-CXCR4 signaling has been reported to be involved in migration of cancer cells, including …
Web16 Feb 2005 · The high level of homology between SDF-1a and SDF-1b and the equal homology between them and human SDF-1 suggests that SDF-1a and SDF-1b are duplicates much like many other genes in teleost genomes ( Postlethwait et al., 2000 ). The two sdf-1 genes are expressed in specific and dynamic patterns with little overlap ( Li et … Web6 Feb 2024 · SDF-1α Gene-Activated Collagen Scaffold Restores Pro-Angiogenic Wound Healing Features in Human Diabetic Adipose-Derived Stem Cells SDF-1α Gene …
WebHuman: Expression System: E. coli Amino acid sequence: Human SDF, amino acids Lys22-Lys89: Molecular weight: 8 kDa: Class: Recombinant: Type: Protein: Purity >98% by SDS-PAGE: Endotoxin concentration: 0.01 ng/µg: Activity: ED50 = 8 – 120 ng/mL; Bioactivity was measured by its property to chemoattract resting human T cells in a dose … WebMAGNETIC SEPARATION ENABLED Human Group I and Human Group II Panels Human IL-17 MFI 16,000 12,000 8,000 4,000 0 1 10 100 1,000 10,000 100,000 Concentration, pg/ml ... 171-B6019M SDF-1a Set 171-B6020M TNF-b Set 171-B6021M TRAIL Set 171-B6022M VCAM-1 Set*** Created Date:
WebPretreatment with GLP-1(1-37) reduced the SDF-induced migration of isolated human CD4-positive lymphocytes in a concentration-dependent manner. Similar effects were seen when RANTES was used as a chemokine. GLP-1(1-37)'s effect on CD4-positive lymphocyte migration was mediated through an early inhibition of chemokine-induced PI-3 kinase ...
WebHuman SDF 1a Recombinant Protein (RPPB1247) SKU: RPPB1247 Product type: Recombinant Protein Size: 10ug Species: Human Target: SDF 1a Synonyms: SDF-1 Synonyms: CXCL12 Synonyms: Pre-B cell growth-stimulating factor Synonyms: PBSF Source: Escherichia Coli Uniprot: P48061 €245 Quantity: Add selected to cart … reaper latency monitoringWebSix human SDF-1 isoforms exist due to alternative splicing of CXCL12, the gene encoding SDF-1. Three isoforms are known for mouse and rat. ... SDF-1 (P-159X) is recommended for detection of SDF-1a and SDF-1b of mouse, rat and human origin by Western Blotting (starting dilution 1:200, dilution range 1:100-1:1000), immunofluorescence (starting ... reaper layout boatWebStromal cell-derived factor-1 (SDF-1) was produced by stromal and other cell types. SDF-1 and its receptor CXCR4 were involved in the mobilizing and trafficking of ... bodies, as well as with standard recombinant human SDF-1a (R&D Systems, USA). The ELISA conditions for Med Oncol (2011) 28:S494–S500 S495 123. reaper launcherWebBioassay analysis of Human CXCL12 (SDF-1a) Recombinant Protein, PeproTech® (Product # 300-28A-1MG). Product Details Product Specific Information Recombinant Human … reaper latency settingsWebobvious application of the knowledge obtained on the SDF-1-HS complex is the engineering of drugs blocking human immunodeficiency virus CXCR4 coreceptor. This study was thus undertaken to characterize further the SDF-1a-HS com-plex. It has been previously demonstrated that SDF-1a binds selectively to HS and heparin (a chemically related … reaper lawn mower bladesWeb15 Mar 2007 · SDF-1 is implicated as a chemokine for CXCR4-positive stem cells. 8 It was recently shown that SDF-1 gene expression is regulated by the transcription factor hypoxia-inducible factor-1 (HIF-1) in endothelial cells, resulting in selective in vivo expression of SDF-1 in ischemic tissue. 9 From the latter study, it was concluded that recruitment of CXCR4 … reaper lcg chassisWebB5MCZ3_HUMAN: IL6: 189: A0A8Q3SJL1: A0A8Q3SJL1_HUMAN: IL6: 266: Polymorphism. Genetic variations in IL6 may be correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disruption of bone microarchitecture, and the alteration of the … reaper lehew