WebApr 7, 2024 · Immune landscape and the key role of APOE+ monocytes of lupus nephritis under the single‐cell and spatial transcriptional vista - PMC Back to Top Skip to main … WebApr 8, 2024 · Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease. Knowledge of circulating immune cell types and states associated with SLE remains incomplete. We profiled more than 1.2 million peripheral blood mononuclear cells (162 cases, 99 controls) with multiplexed single-cell RNA sequencing (mux-seq).
Is lupus genetic? Lupus Foundation of America
WebAug 22, 2024 · While they have successfully identified several cell clusters crucial for lupus pathogenesis, they failed to detect some established cell subpopulations, for example, T helper 1 (Th1), 17 (Th17), and neutrophils (Neu), mainly due to the sparse expression at single-cell level (around 1,000 genes per cell). WebMar 15, 2024 · Single-cell transcriptomic analyses of lupus nephritis (LN) kidney biopsies have suggested a role for cytotoxic T cell subsets in the kidneys of affected patients, with populations of NK cells, cytotoxic T cells, and granzyme K + CD8 + T cells all being highly represented among lymphocytes in kidney biopsies ( 13 ). mo family safety registry
Predicting disease flares in systemic lupus erythematosus using single ...
WebAug 3, 2024 · Lupus nephritis (LN) is one of the most common and severe complications of lupus. However, the mechanisms for renal damage have not been well elucidated. There are evidences show that glomerular endothelial cells (GECs) are damaged in LN. Immune complexes can deposit in subendothelial area and could affect GEC functions. In the … WebSingle-cell RNA sequencing (scRNA-seq) has recently undergone rapid advances in the development of this technology, leading to high throughput and accelerating discovery in … WebMar 22, 2024 · Single-cell RNA sequencing independently demonstrated that IL16 is the second most expressed cytokine by most infiltrating immune cells in LN kidneys. IL-16-producing cells were found at key sites of kidney injury. mofa motobecane mobylette