Mechanistic understanding of human slfn11
WebMar 31, 2024 · Mechanistic understanding of human SLFN11. Metzner, F.J. , Wenzl, S.J. , Kugler, M. , Krebs, S. , Hopfner, K.P. , Lammens, K. (2024) Nat Commun 13: 5464-5464 … WebSep 17, 2024 · 17.09.2024 Schlafen 11 (SLFN11) is an interferon-inducible antiviral restriction factor with tRNA endoribonuclease and DNA binding functions. It is recruited to stalled replication forks in response to replication stress and inhibits replication of certain viruses such as the human immunodeficiency virus 1 (HIV-1) by modulating the tRNA pool.
Mechanistic understanding of human slfn11
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WebAug 29, 2024 · SLFN11 is expressed in monocytes and monocyte-derived dendritic cells [ 51] and is upregulated in monocyte-derived dendritic cells upon exposure to IFN-α, LPS, or rhinovirus [ 51 ]. Similar to SLFN5, SLFN11 has been identified as part of the NOTCH1 nuclear interactome [ 53 ]. WebDec 18, 2024 · For the aforementioned agents, and in multiple cancer cell line panels, the presence of SLFN11 has been shown to correlate with sensitivity, whereas the low or absent expression has been...
WebOct 4, 2024 · Human Schlafen 11 ( SLFN11) is an interferon-stimulated gene (ISG) that we previously have demonstrated to ablate translation of HIV proteins based on the virus's distinct codon preference. Additionally, lack of SLFN11 expression has been linked to the resistance of cancer cells to DNA-damaging agents (DDAs). WebApr 4, 2024 · SLFN11 is Widely Expressed in Pediatric Sarcoma and Induces Variable Sensitization to Replicative Stress Caused By DNA-Damaging Agents. SLFN11 captures …
WebRecently, the Schlafen (SLFN) proteins have been identified as a novel interferon-stimulated family with antiviral properties. In this study, we reported that SLFN11 inhibited prototype foamy virus (PFV) replication. Over-expression of human SLFN11 reduced viral production, while knockdown of SLFN11 … WebDec 9, 2015 · Understanding the molecular mechanisms behind SLFN11 involvement in DNA damage response will help clarify its clinical importance and may pave the way for human cancer therapies. In this study, we have provided several lines of evidence to show that SLFN11 is a novel endogenous inhibitor of DNA damage response in cancer cells …
WebJan 21, 2024 · The Schlafen ( SLFN) family was first described as a set of homologous genes that are involved in T-cell development and inhibit cell growth. 1 These genes are found only in mammals and a small number of nonmammalian species. 2 A member of the SLFN family, SLFN11, is a putative DNA/RNA helicase ubiquitously expressed in the …
WebSep 17, 2024 · The mode of ssDNA binding by dimeric SLFN11 suggests a mechanism how the protein might block stalled replication forks. Taken together, our manuscript describes a new avenue to a mechanistic... jiomart bank offerWebMar 31, 2024 · Human SLFN11 dimer bound to ssDNA PDB DOI: 10.2210/pdb7ZES/pdb EM Map EMD-14692: EMDB EMDataResource Classification: HYDROLASE Organism (s): … instant pot chunky beef chili recipeWebSep 17, 2024 · SLFN11 has been identified as a predictive biomarker in cancer, as its expression correlates with a beneficial response to DNA damage inducing anticancer … jiomart clothesWebSLFN11 forms a homodimer with the heli- case domains adopting an autoinhibited conformation. Guided by the structures, we predict amino acid exchanges that selectively … jio mart bank offersWebJun 29, 2024 · Here, we describe the main characteristics of the human SLFN gene family and focus on the emerging structural insights related to SLFN11’s potential endoribonuclease and helicase/ATPase... jio mall online shoppingWebApr 14, 2024 · Pretoria, Republic of South Africa In furtherance of the joint declaration made by the two principal regional human rights bodies on 27 March 2024, to strengthen and institutionalize their strategic cooperation, including by signing a Memorandum of Understanding (MoU) and developing a roadmap of joint activities, delegations of the … instant pot chutney recipeWebApr 12, 2024 · We explored the effect of thrombin on human aortic smooth muscle cells (HASMCs) and further analyzed its role in the pathogenesis of atherosclerosis (AS). Thrombin-induced differentially expressed genes (DEGs) in HASMCs were identified by analyzing expression profiles from the GEO. Subsequently, enrichment analysis, GSEA, PPI … jio main office near me