Rootletin cochlea
WebJul 2, 2015 · In vertebrates, rootletin is the major structural component of the ciliary rootlet and is also part of the tether linking the centrioles of the centrosome. Various functions have been ascribed to the rootlet, including maintenance of ciliary integrity through anchoring and facilitation of transport to the cilium or at the base of the cilium. In Drosophila, Rootletin … WebMajor structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends …
Rootletin cochlea
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WebFeb 1, 2015 · Following microdissection of the cochlea and utricle, immunohistochemistry was performed as described (May-Simera and Kelley, 2012a). Images were obtained … WebRootletin also known as ciliary rootlet coiled-coil protein (CROCC) is a protein that in humans is encoded by the CROCC gene. [1] [2] [3] Rootletin is a component of the ciliary rootlet, …
WebNov 11, 2002 · Rootletin is a component of the rootlet in all ciliated cells To confirm that rootletin is indeed a component of the rootlet, two antibodies directed against different … WebApr 13, 2024 · Rootlets are cytoskeleton-like structures that project from the proximal end of the basal body and are thought to be composed primarily of the ∼225 kDa protein …
WebNov 11, 2002 · Model for assembly of rootlet from rootletin monomers. Filled segment of the monomer is predicted to form a coiled-coil structure. The homodimer is parallel and in axial register. The characteristic cross striation is likely the result of alternating protein-packing densities. KLC3 has been shown to interact physically with the head domain of ... WebHere we report that Drosophila melanogaster Rootletin (Root), the sole orthologue of the mammalian paralogs Rootletin and C-Nap1, assembles into rootlets of diverse lengths among sensory neuron subtypes. Root mutant neurons lack root - lets and have dramatically impaired sensory function, resulting in behavior defects associated with ...
WebMar 29, 2024 · Title: Rootletin prevents Cep68 from VHL-mediated proteasomal degradation to maintain centrosome cohesion. we demonstrated that TAX1BP2 was frequently …
WebOct 23, 2024 · Rootletin is the main component of the ciliary rootlet and functions as a centriole linker connecting the two mother centrioles. Despite the functional importance of rootletin, the molecular architecture of the rootletin filament and its assembly mechanism are poorly understood. Here, we identify the coiled-coil domain 3 (CCD3) of rootletin as ... emkay enersys car insuranceWebRootletin/CEP68 filaments form an extended, web-like network that spreads up to 1 to 2 µm outward from the C-Nap1 ring at the proximal end of both centrioles. Rootletin filaments … emkay fleet claims numberWebApr 15, 2024 · Screening a number of markers of steps in the ciliation pathway supports a model in which ELMOD2, Rootletin, and ARL2 act downstream of TTBK2 and upstream of CP110 to prevent spurious release of CP110 and to regulate ciliary vesicle docking. These data thus provide evidence supporting roles for ELMOD2, Rootletin, and ARL2 in the … emkay fleet leasingWeb301 Moved Permanently. nginx emkay exhaust fan 24 inchWebJul 6, 2024 · A cochlear implant is an electronic device that can improve hearing in individuals who experience deafness or profound hearing loss as a result of damage to … emkay cursed imagesWebMar 31, 2016 · Rootletin shares significant structural similarity with the centrosomal protein Cnap1 (CEP2; 609689). Western blot analysis detected rootletin at an apparent molecular … emkay drip protectorsWebMar 21, 2024 · Ciliary rootlet coiled-coil protein 2 Protein Accession: H7BZ55 Protein attributes for CROCC2 Gene Size: 1653 amino acids Molecular mass: 185641 Da Protein existence level: PE1 Quaternary structure: No Data Available Three dimensional structure from AlphaFold (predicted) for CROCC2 Gene IMPROVED Click for interactive 3D structure … emkay fleet maintenance phone number