Web2 Nov 2024 · The engineered Salmonella typhimurium ΔppGpp ( S.t ΔppGpp) has been studied in terms of its ability to carry imaging probes (bacterial luciferase, Lux) for tumor imaging or carry therapeutic molecules (Cytolysin A) to kill cancer cells. Web30 Apr 2024 · This was shown to favour the niche for S. Typhimurium in the tumour-bearing mice compared to tumour-free mice (Lee et al. 2010; Chirullo et al. 2015). The role of …
Genetically engineered Salmonella typhimurium for targeted …
Web4 Jan 2010 · Here, we engineered attenuated S. typhimurium defective in guanosine 5′-diphosphate-3′-diphosphate (ppGpp) synthesis (ΔppGpp strain) to express both the … WebSalmonella Typhimurium defective in guanosine 5′-diphosphate-3′-diphosphate (ppGpp) synthesis (ΔppGpp) is an attenuated strain with good biosafety and excellent anticancer … insurance claims service providers
Radiotherapy combined with an engineered Salmonella
Web28 Apr 2024 · The combination of S. Typhimurium A1-R and low-dose chemotherapeutic drugs, such as temozolomide, doxorubicin and anti-angiogenic agents, also significantly … Web30 Apr 2024 · A mutant strain of Salmonella (ΔppGpp) carrying deletion of relA and spoT genes has been shown to trigger the expression of tumour inhibitory cytokine genes including IL-18, IL-1β and TNF-α and inflammasome coding genes such as NLRP3, IPAF in MC38 and CT26 in colon cancer murine models (Na et al. 2006; Kim et al. 2015a; Phan et … Web14 Aug 2024 · ΔppGpp S. typhimurium prepared by the reported method was obtained from the Third Xiangya Hospital of Central South University and stored at −80°C. For bacterial … insurance claims statistics by state