WebSystematic profiling of tumors with defined splicing deficiencies conducted with the use of bulk and single-cell RNA sequencing and coupled with mass spectrometry would provide … WebIn this study, we report the effect of splicing modulation on key proteins in the p53 signalling pathway, an important cell death pathway in B cells. Splicing modulation by E7107 treatment reduced full-length MDM2 production due to exon skipping, generating a consequent reciprocal p53 increase in TP53WT cells. It was especially noteworthy that ...
Splicing modulators: on the way from nature to clinic
Web1 Apr 2003 · The spliceosomal machinery is responsible for the processing of nuclear RNA. Several splicing factors associated with this complex are phosphorylated by kinases that possess a conserved LAMMER motif. We demonstrate in BY-2 tobacco cells a novel role for the LAMMER motif in the maintenance of proper subnuclear localization. Web2 days ago · Alternative splicing (AS) in plants plays a key role in regulating the expression of numerous transcripts from a single gene in a regulatory pathway. Variable concentrations of growth regulatory hormones and external stimuli trigger alternative splicing to switch among different growth stages and adapt to environmental stresses. In the AS … lyric vs tesla y
Alternative splicing modulation mediated by G-quadruplex …
Web10 hours ago · Lu, S. X. et al. Pharmacologic modulation of RNA splicing enhances anti-tumor immunity. Cell 184 , 4032–4047.e31 (2024). Article CAS PubMed PubMed Central Google Scholar WebSplicing modulation therapy in the treatment of genetic diseases. Antisense-mediated splicing modulation is a tool that can be exploited in several ways to provide a potential therapy for rare ... Web11 Jan 2013 · Sustained activation of X-box-binding protein 1 (XBP1) results in endothelial cell (EC) apoptosis and atherosclerosis development. The present study provides evidence that XBP1 mRNA splicing triggered an autophagic response in ECs by inducing autophagic vesicle formation and markers of autophagy BECLIN-1 and microtubule-associated … kishwaukee river state fish and wildlife area