WebWe hypothesized that this discrepancy suggests the existence of a second MIF-like molecule, possibly a protein encoded by the homologous D-dopachrome tautomerase, D-DT (DDT) gene. The genes for MIF and D-DT are located in close proximity to each other and genetic analysis suggests that the genes arose by an ancestral duplication event. WebA cell-permeable iodo-pyrimidine compound that covalently modifies MIF N-terminal proline and exhibits higher MIF inhibitory potency than ISO-1 (Cat. No. 475837) in cell-free dopachrome tautomerase activity assays (IC 50 ~5 vs. 50 µM, respectively, using recombinant human MIF) as well as in cell-based migration assays (50% vs 0% inhibition ...
Full article: Tetralone derivatives are MIF tautomerase …
WebJan 2, 2002 · MIF was discovered to tautomerize the nonphysiological substrates D-dopachrome and L-dopachrome methyl ester (ref. 25; Fig. 1).Elucidation of the three … WebTherefore, MIF is considered a viable therapeutic target for treating inflammatory diseases and neoplasia. In addition to its physiologic and pathophysiologic activities, MIF is known to act as a tautomerase and has a catalytically active N-terminal proline that is invariant in structurally homologous bacterial isomerases. erin mitchell cynchealth
Human Gene DDT (uc002zyz.4)
WebJul 15, 2024 · At 12h, 24h and 48h after the surgery, the rats in each group were sacrificed. Immunofluorescence staining for macrophage marker (ED-1), the tautomerase activity of macrophage inhibitory factor (MIF) assay and real-time PCR analysis for interleukin-1β (IL-1β) and matrix metalloproteinase-9 (MMP-9) were performed. WebMacrophage migration inhibitory factor (MIF) is a mammalian cytokine that participates in innate and ... Like human MIF, histidine-tagged purified recombinant PMIF shows tautomerase and oxidoreductase activities (although the activities are reduced compared to those of histidine-tagged human MIF) and efficiently inhibits AP-1 activity in ... WebJan 23, 2007 · Function. Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens ( By similarity ). The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense ( By similarity ). Counteracts the anti-inflammatory activity of glucocorticoids ( By similarity ... find where pip installed a package