Trifluoromethylthiolating
WebShanghai Institute of Organic Chemistry, Chinese Academy of Sciences. 2013 年 8 月 - 2014 年 2 月7 个月. shanghai. worked as assistant professor in Prof. Guosheng Liu's lab focusing on the Cu-catalyzed C-F bond formation reactions and mentor graduate students. WebApr 2, 2024 · Chinese Chemical Letters 2024年1期. Chinese Chemical Letters的其它文章 Diverse synthesis of the C ring fragment of bryostatins via Zn/Cu-promoted conjugate addition of α-hydroxy iodide with enone
Trifluoromethylthiolating
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WebAug 26, 2024 · Here we describe a deoxygenative trifluoromethylthiolation method that yields trifluoromethyl thioesters from readily available carboxylic acids. The method is built upon an “umpolung” strategy where triphenylphosphine is used to first activate an electrophilic trifluoromethylthiolating reagent and then serves as an oxygen acceptor for … WebA transition-metal-free direct trifluoromethylthiolation of indole derivatives under mild conditions has been developed. Commercially available sodium trifluoromethanesulfinate …
WebJun 5, 2024 · a, Asymmetric trifluoromethylthiolation with electrophilic trifluoromethylthiolating reagents. b , Asymmetric trifluoromethylthiolation through enantioselective Doyle–Kirmse reaction. Full size ... WebMay 20, 2014 · Furthermore, we also achieved the oxidative trifluoromethylthiolation reactions of aryl boronic acids and terminal alkynes to construct carbon-SCF3 bonds by using CF3SiMe3 and elemental sulfur as the nucleophilic trifluoromethylthiolating reagent.
WebA boron-catalyzed direct α-trifluoromethylthiolation of carboxylic acids was developed. Catalytically generated boron enediolates reacts with electrophilic SCF3 reagent, N-SCF3-phthalimide, to provide α-SCF3 carboxylic acids without the need of substrate pre-activation. The method is applicable to direct modification of bioactive carboxylic ... WebAug 15, 2024 · Electrophilicity parameters (E) of some popular trifluoromethylthiolating and difluoromethylthiolating reagents were determined by following the kinetics of their reactions with a series of ...
WebJul 24, 2024 · A multicomponent catalytic reaction between ketones, Morita–Baylis–Hillman (MBH) carbonates and trifluoromethylthiolating agents is devised for straightforwardly …
WebOct 25, 2024 · The only successful benzylic C–H trifluoromethylthiolation strategy is copper-catalyzed oxidative trifluoromethylthiolation with AgSCF 3 but the reaction needs a large excess of simple toluene ... eventi fashion week milano 2022WebMay 19, 2015 · To address these problems, in late 2011 we initiated a project with the aim to develop new, shelf-stable, and highly reactive electrophilic trifluoromethylthiolating … eventi foodWebThis important transformation process has been applied in several elegant decarboxylative fluorinations. 8 Shen and co-workers described the silver-catalyzed oxidative decarboxylative trifluoromethylthiolation of alkyl carboxylic acids with electrophilic trifluoromethylthiolating reagent I in an aqueous emulsion . 8b Very recently, Glorius ... eventi fashion week milano 2023WebJul 6, 2024 · A mild and efficient Cu-assisted trifluoromethylthiolation/radical cascade cyclization of alkynes with readily available and stable AgSCF 3 as the trifluoromethylthiolating reagent has been disclosed. This transformation provides an opportunity to construct a series of potential medicinally valuable trifluoromethylthio … first horizon bank wolf riverWebSubstitution by the CF 3 S group allows for an increase in lipophilicity and electron-withdrawing properties along with an improvement in the bioavailability of medicinal … first horizon bentonville arWebMay 22, 2024 · Trifluoromethylthiolating reagent 3 was synthesized according to a procedure by Shen and co-workers. (23) Trifluoromethylating reagent 6a … first horizon boiling springsWebIn this context, Liang's research group developed an operationally simple method for the direct trifluoromethylthiolation–difluoroalkylation of alkenes employing (bpy)CuSCF 3 (bpy = 2,2′-bipyridine) and ethyl iododifluoroacetate (ICF 2 CO 2 Et) as trifluoromethylthiolating and difluoroalkylating reagents, respectively. 13 Various styrene derivatives 4 slowly reacted … eventi go wine